Where would you expect to see the ligand binding site of a neurotransmitter-gated ion channel protein?.

Answers

Answer 1

Transmembrane ion channels known as ligand-gated ion channels open or shut (controlled passage) in response to the interaction of a chemical signalling agent such as a ligand.

An essential family of plasma membrane proteins known as ligand gated ion channels (LGIC) mediates cell-cell communication and cellular excitability. The electrically excitable cells like neurons are a fairly typical location to discover ligand-gated ion channels.

Ligand-gated ion channels (LGICs) are membrane proteins that are structurally integral and feature a pore that permits the controlled passage of certain ions across the plasma membrane. The electrochemical gradient for the permeant ions drives the passive ion flow.

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Related Questions

which animal has a long and curved lumbar region, and which has a short and stiff lumbar region? how does this contribute to an erect posture in humans?

Answers

The lumbar area of chimpanzees is short and rigid. The lumbar area is lengthy and curved in humans. Our weight is balanced as a

What makes it the lumbar region?

The term "lumbar" refers to the abdominal region of the torso, which is located here between diaphragm and the sacrum, in tetrapod anatomy. The lower spine or a portion of the back near it are terms that are sometimes used to describe the lumbar region.

What causes soreness in the lower back?

A strain (injury) to the back's muscles or tendons may cause it. Injuries to the disks, structural issues, and arthritis are further causes. Rest, physical therapy, and medication can all help with pain. Maintaining a healthy weight and remaining active will lower your risk of developing low back discomfort.

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biodiversity is partially influenced by net primary productivity. where can the highest terrestrial rates of npp be found? question 24 options: polar regions tundra deciduous forests deserts tropical rainforests

Answers

Tropical rain forests possess high NPP and the highest levels of biological diversity among terrestrial environments.

What constitutes the tropical rain forest ?

A tropical rainforest is a lush, steamy, and thriving forest that is typically found around the equator. Tropical rainforests have towering broad-leaved evergreen trees that form a continuous canopy and receive about 100 inches (254 cm) of rainfall annually.

Rainforests come in many distinct varieties.

Less than 3 percent of the earth is covered in rainforests.

The Amazon rainforest is the biggest rainforest in the world.

More plant and animal species can be found in rainforests than in any other terrestrial ecosystem.

In the rainforest, trees are home to a large portion of the life.

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Genetic variation among humans is relatively small when compared to other species. Where in the human genome does most of the diversity occur?.

Answers

In the human genome most of the diversity occur in is in the sequences that code for tRNA(Transfer RNA).

Human ancestral lines are relatively young compared to other species. Man is a genetically homogeneous species. Although a small number of genetic variants are found more frequently in certain geographic regions or in people with ancestry from those regions, this variation represents a small percentage of the human genome. They are transcribed by RNA polymerase III (Pol III) and go through a series of processing steps and post-transcriptional modifications to become fully active. tRNA also exhibits great sequence diversity in the human genome, but the tRNA gene sequence variation and potential functional implications in individual human genomes have not been studied. Human genetic variation is the genetic differences within and between populations. There can be several variants of a given gene in the human population (alleles), a situation called polymorphism.

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Even though horses and donkeys look very similar they are not really the same_?

A. biology
B. genetic variation
C. organism
D. population
E. species
F. environment
G. offspring
H. overproduction
i. reproduction
D.

Answers

E, they are not the same species because hybrid offspring are non viable

8. Which of the following is an example of a homeostatic reinforcing feedback loop? Please HIGHLIGHT your selection and explain below.

Andrew was mountain biking and fell and wounded his knee. When tissue is torn or injured, a chemical is released. This chemical causes platelets in the blood to activate. Once these platelets have activated, they release a chemical which signals more platelets to activate, until the wound is clotted.
While exercising, Julia's heart rate and breathing increase to balance the increased oxygen use by her muscle cells.
On a hot day, Martin doesn't drink very much water. His kidneys respond by removing very little water from his blood, resulting in yellow, concentrated urine.
After eating a candy bar, April's pancreas secretes insulin, causing excess blood sugar to be removed.

Answers

Blood sugar is an example of a homeostatic reinforcing feedback loop.

What is homeostasis?

homeostasis is the state of the  steady internal, physical, and chemical of  conditions maintained by living things , organisms and systems. This is the condition of optimal by to the  functioning for the organisms and included many of the variables, such as body temperatures and the body  fluid balance, beings kept within certain pre-set limits.

Examples of processes that is  utilise negative feedback and  loops include homeostatic by the systems, such as: Thermoregulation (if body temperature changes, mechanisms are the  induced to restore normal levels) Blood and  sugar regulation (insulin lowers blood glucose when it is the  levels are high ; glucagon raises blood by  glucose when levels are low)

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The process of antibody production after initial exposure to an antigen is known as the _________ response.
Lag
Latent
Primary
Secondary

Answers

The process of antibody production after initial exposure to an antigen is known as the Primary response.

What is the name of the initial antigen exposure?Primary response refers to the immune response that develops after being exposed to an antigen for the first time. The immune response that develops after a second or additional exposures to an antigen, stronger and quicker, is referred to as a secondary reaction.A process known as somatic hypermutation enables the B cell to start coding for a new antibody after antigen presentation to the B cell lymphocytes has taken place. This antibody will have a distinctive Antigen Binding Site in the variable region that can bind specifically to an epitope from the antigen.

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when gonorrhea disseminates to other tissues, it most often affects the: a. joints. b. colon. c. liver. d. kidneys.

Answers

Although gonorrhea can spread to other tissues, the joints are the most frequently affected. An STD called gonorrhea can infect the throat, genitalia, and rectum.

What impacts a person who has gonorrhea?

Including the cervix, uterus, or fallopian tubes in women, as well as the urethra in both men and women, gonorrhoeae affects the mucosal membranes of the reproductive tract. The mucosal lining of the face, throat, eyes, the rectum are also susceptible to N. gonorrhoeae infection.

what is Gonorrhea is a contagious disease.

Having , , or oral intercourse is the most common way for people to contract gonorrhea. If you have gonorrhea-infected fluids on your hand, you can also contract the disease by touching your eye. In addition, if the woman has gonorrhea, it might be passed to the kid during birth.

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The sorting that occurs during blank______ separates homologues from each other.

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The sorting that occurs during blank Meiosis 1 separates homologues from each other. Meiosis uses a two-step division mechanism to achieve these goals.

During the initial round of cell division, known as meiosis I, homologue pairs split apart. Sister chromatids split apart during meiosis II, the second round.

Disjunction describes the division of homologous chromosomes during anaphase I. Disjunction is a crucial component of the anaphase processes of mitosis and meiosis (I and II). Sister chromatids split and travel to the polar opposites of the cell during the anaphase of mitosis.

In prophase I of meiosis, homologous chromosomes are paired; they are then split apart in anaphase I, resulting in a halving of the number of chromosomes.

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Alculate NEP before the outbreak and identify the most appropriate conclusion about whether the forest was a carbon sink or a carbon source. Calculate NEP before the outbreak and identify the most appropriate conclusion about whether the forest was a carbon sink or a carbon source. Before the outbreak, the forest was a carbon sink because NEP was less than 0. Before the outbreak, the forest was a carbon sink because NEP was greater than 0. Before the outbreak, the forest was a carbon source because NEP was less than 0. Before the outbreak, the forest was a carbon source because NEP was greater than 0

Answers

Because NEP was higher than 0 before to the outbreak, the forest served as a carbon sink.

What is Net ecosystem production (NEP)?

The total amount of organic carbon in an ecosystem that is available for storage, export as organic carbon, or non biological oxidation to carbon dioxide through fire or ultraviolet oxidation is represented by net ecosystem production (NEP), which is defined as the difference between gross primary production and total ecosystem respiration.

Comparing the total output and total respiration of all the creatures in an ecosystem

NEP = GPP-(Ra + Rh)

R = Autotrophic respiration

Rh stands for hetertrophic respiration.

NEP can be either good or bad.

The forest is a carbon sink since its NEP is larger than zero, just as it was before the outbreak because there will be some or more NEP. After the outbreak, however, the forest system will be disturbed, NEP will be less than zero, and the forest will turn into a carbon source.

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I do not understand how to do this. Pls, explain.

Answers

Answer:

The answer should be A. They could have genotype Cc or cc

Explanation:

        C     c

 [tex]{c}\\{c}[/tex]   [tex]\left[\begin{array}{ccc}Cc&cc\\Cc&cc\end{array}\right][/tex]

I tried to make a punnet square as best as I could..

To jog your memory about the basics of punnet squares and what certain words mean.

Dominance is shown by a capital letter, while recessive is denoted by lowercase

If a person is homozygous they carry two identical alleles (CC or cc).

Two capitals mean a person is homozygous dominant, whilst two lowercase means a person is homozygous recessive.

If a person is heterozygous that means that they carry two different alleles, one dominant and one recessive (Cc).

The dominant allele will always be present over the recessive.

As the statement shows, individual 5 is heterozygous, meaning their genotype is Cc.

Their partner is a shaded individual, which means they have cystic fibrosis, which is homozygous recessive. This means their genotype is cc.

When doing a punnet square, you will see the two outcomes of possible genotypes are Cc and cc. This means there is a 50% (or 2/4) chance of individual 12 being healthy (Cc), or there is a 50% (or 2/4) chance of the individual having cystic fibrosis (cc).

the movement of phosphorus from the environment to organisms and then back to the environment?

Answers

The movement of phosphorus from the environment to oraganism and back is called the Phosphorus cycle.

The repeated movement of a specific nutrient or element through one or more organisms and back to the environment is known as a "nutrient cycle."

Phosphorus is a crucial component for all living things. It contributes significantly to DNA and RNA's structural foundation.

They are a crucial part of ATP as well.

Phosphorus makes up 80% of the bones and teeth in humans.

The phosphorus cycle progresses very slowly. The phosphorus in the rocks is washed into the soil by a number of weather-related processes. The organic matter in the soil, which is used for numerous biological activities, absorbs phosphorus.

Since phosphorus and compounds containing phosphorus are only found on land, the atmosphere has little impact on the phosphorus cycle.

Following are the important steps of phosphorus cycle:

1.Weathering

2.Absorption by Plants

3.Absorption by Animals

4.Return to the Environment through Decomposition

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One problem with getting mrna vaccines to work was that the immune system responded and destroyed the rna too quickly. How did the immune system recognize the foreign rna?.

Answers

The immune system recognizes the foreign RNA due to the presence of pattern recognition receptors (PRRs) on APCs that recognize the foreign microbes.

RNA is the genetic material. It is the unstable nucleic acid present in pathogens like viruses as the genetic material. The full form of RNA is Ribonucleic Acid.

PRRs are the crucial proteins of innate immunity. These are the receptors that recognize and bind with the molecules present on the pathogens. This triggers the immune system to activate various immune cells that protect the living organism. The cells that possess PRR are: macrophages, dendritic cells (DCs), monocytes, and B lymphocytes.

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Is the fallowing true or false
An average star spends 90 percent of its life as a helium-burning main-sequence star?

Answers

Answer:false because the start must be the yellow star and other is can not make it true

the following structure is that of galactose. is this a furanose or pyranose form? is it an alpha or beta anomer? is it a d or l sugar?

Answers

The following structure is pyranose form of the galactose as the given cyclic shape incorporates 5 carbon atoms and one oxygen atom forming a 6-membered heterocyclic sugar.

The cyclic shape of sugar is assessed as furanose or pyranose sugar primarily based totally at the range of atoms that bureaucracy the ring. A pyranose shape of sugar is a 6-membered ring that includes 5 carbon atoms and one oxygen atom. They are shaped with the aid of using sugars with an aldehyde useful organization.

A 5-membered cyclic shape of sugar is known as a furanose ring with 4 carbon atoms and one oxygen atom. They are shaped while the sugar has a ketone organization withinside the 2nd position.

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organism a is eukaryotic, unicellular, and lacks a cell wall. organism b is eukaryotic, multicellular, has cell walls, and is autotrophic. in which kingdoms should these organisms be classified?

Answers

The Kingdom Animalia stands apart among them due to the presence of multicellular bodies, a heterotrophic source of nutrition, eukaryotic cells, and cells without a cell wall.

The five Kingdom system has been used to group all creatures into these five categories. The Kingdom Animalia stands out among them due to the presence of multicellular organisms, a heterotrophic mode of nutrition, eukaryotic cells, and cells without a cell wall.

Members of the kingdom Monera include unicellular prokaryotic BGA and bacteria. Algae, every type of protozoa, and eukaryotic unicellular organisms are all included in the Protista kingdom. The kingdom fungus includes multicellular heterotrophic eukaryotes with chitinous cell walls. Kingdom Plantae is home to autotrophic organisms with cellulose cell walls while kingdom Animalia is home to heterotrophic animals without one.

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Identify the Salute and olvent in a olution made from 15 gram of oxygen and 5 gram of helium

Answers

Oxygen is the solvent and helium is the solute.

What is a solute and solvent ?

To create a homogenous mixture, a solute must dissolve in a solvent. The substance that dissolves in a solvent to create a homogeneous mixture is known as a solute.

The substance that typically determines the solution's physical state is the solvent (solid, liquid or gas). The substance that dissolves in the solvent is known as a solute. For instance, in a solution of salt and water, salt serves as the solute and water as the solvent.

In fluid solutions, there is a larger concentration of solvent than solute. Salt and water are two excellent examples of substances that we use on a daily basis. Since salt dissolves in water, it serves as the solute.

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3. can be triggered by airborne substances, foods or common bacteria and viruses

6. spasms can cause wheezing

8. excess mucus in the body

Answers

Answer:

3. Airborne diseases are illnesses spread by tiny pathogens in the air. These can be bacteria, fungi, or viruses, but they are all transmitted through airborne contact. In most cases, an airborne disease is contracted when someone breathes in infected air.

6. If you have a respiratory problem, such as asthma, these muscles can contract and narrow your airway. When that happens, it's called a bronchial spasm, or a bronchospasm. During a bronchial spasm, breathing becomes more difficult. You may find yourself wheezing as you try to catch your breath.

8. What causes excessive mucus? Smoking or exposure to an irritant in the air may cause you to produce more mucus than usual. If the mucus is clear, you might have allergies. Other conditions that could cause excess mucus include bronchitis, chronic obstructive pulmonary disease, and cystic fibrosis.

Explanation:

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tropical rainforests have high species richness, but low density. in deciduous forests the pattern is the opposite. which of the statements is not a plausible explanation for this pattern?

Answers

There are fewer species in temperate regions because the number of trees per hectare is lower than in tropical rainforests.

What is deciduous forests and tropical rainforests ?

Due to the trees in tropical deciduous forests losing their leaves in the dry season and growing new ones in the monsoon, these forests are also known as monsoon forests.

A deciduous forest is distinguished by its deciduous trees and plants, which lose their leaves every year, typically in the winter. Since the plants' height and shape vary, forests are typically very dense. Deciduous refers to plants and trees that have a tendency to fall, from which the name derives.

The tropics, or between latitudes of 23.5°N (the Tropic of Cancer) and 23.5°S (the Tropic of Capricorn), is where tropical rainforests are primarily found. On the islands of New Guinea, Australia, Central and South America, western and central Africa, western India, and Southeast Asia, there are tropical rainforests.

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a section through the thigh shows the muscle compartments. regarding the muscles indicated by the number 1, what action do they have on the knee?

Answers

The muscles of the thigh is divided into three compartments: anterior compartment, medial compartment and posterior compartment. Function of anterior compartment muscles is to extend lower limb at knee joint.

How are thigh muscles and knee related?

The medial thigh muscles allows for adduction of the leg. Weak adductor muscles can cause knee instability and increase the risk of an adductor strain. Medial thigh muscles protect important neurovascular structures as they pass from the proximal hip joint to knee and lower leg

Weak thigh muscles are common cause of runner's knee, which is a treatable cause of anterior knee pain. Weak thigh muscles allow kneecap to move sideways and rub abnormally against thighbone.

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Santiago always lets the fire in the fireplace on Christmas Eve he needs fuel for the fire which of these represents a fuel?

A paper
B carbon dioxide
C oxygen
D water

Answers

Answer: A. Paper

Explanation: Water is the element what puts out a fire. Oxygen stands alone in the fire triangle, and carbon dioxide is not a physical thing; therefore, it can not fuel a fire. Paper is the only thing that can properly fuel the fire out of these 4 options.

generally, will natural selection result in an increase or decrease in variation? why does this happen and how, in theory, will it affect evolution in the future?

Answers

Natural selection decreases the genetic variation in populations  by selecting for or against a specific gene or gene combination

How does natural selection cause variation?

Genetic variations that alter gene activity introduce different traits in an organism. If a trait is advantageous and helps the individual survive and reproduce, then genetic variation is more likely to be passed on to the next generation, which is known as natural selection.

As natural selection is a mechanism of evolution, organisms that are more adapted to environment are more likely to survive and pass on the genes that aided their success. Therefore, this process causes species to change and diverge over time.

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1, what other molecule is needed for this process to occur?

2, what energy-carrying molecule is created in this process?

3, on what organelle does this process occur?

4, what is this process called?

5, what type of cells have more mitochondria than others? Why?

6, in humans (and other animals) where does this glucose come from?

7, why does respiration increase during exercise?

Answers

Answer:

1. cellular respiration

2. ATP

3. Mitochondria

4. cellular respiration

5. Heart muscle cells These cells need more energy, so they contain more mitochondria than any other organ in the body

6. Glucose is obtained from food

7. your body uses more oxygen and produces more carbon dioxide

Explanation:

Following are the answers:

1. cellular respiration

2. ATP

3. Mitochondria

4. cellular respiration

5. Heart muscle cells  need more energy, so they contain more mitochondria than any other organ in the body

6. Glucose is obtained from food

7. your body uses more oxygen and produces more carbon dioxide.

ATP (adenosine triphosphate) is needed for this process to occur. ATP is the energy-carrying molecule created in this process. This process primarily occurs in the mitochondria. This process is called cellular respiration. Cells with high energy demands, such as muscle cells, have more mitochondria because mitochondria produce ATP.

Glucose primarily comes from the digestion of carbohydrates in the diet. Respiration increases during exercise to meet the increased energy demands of the muscles and maintain homeostasis.

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Grandpa Minion's genotype for color blindness was: Question 4 options: XCXC XCY XCX XY

Answers

Grandpa Minion's genotype for color blindness would be [tex]X^CY[/tex].

Genotype for color blindness

Color blindness in humans generally is an x-linked or sex-linked, recessive trait.

The sex chromosome of males is XY while that of females is XX. In other words, males can only take a single allele of sex-linked traits because he has only one X chromosome. Thus, males are either affected or unaffected by x-linked traits. There is no chance of being heterozygous or a carrier.

Going by this principle, Grandpa Minion is a male and would have the XY genotype. The X chromosome will carry the color blindness trait either in the dominant or recessive form. Thus, the only plausible option that can pass as the genotype of Grandpa Minion is [tex]X^CY[/tex].

[tex]X^CX^C[/tex] and [tex]X^CX[/tex] can only be for females while in [tex]XY[/tex], there is nothing that indicates the presence of the color blindness allele, be it in dominant or recessive forms.

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50 points!!

Which is true about cell membranes?


Cell membranes consist of a single layer of phospholipids.


Cell membranes are made of lipids and carbohydrates.


Cell membranes are rigid and protect the cell.


Cell membranes form barriers around the cell.

Answers

Answer:

Part of the cell membrane is a phospholipid bilayer,

Explanation:

Cell membranes are composed of proteins and lipids. Since they are made up of mostly lipids, only certain substances can move through. Phospholipids are the most abundant type of lipid found in the membrane. Phospholipids are made up of two layers, the outer and inner layers., made of two layers of phospholipid molecules. However, the cell membrane also contains other macromolecules like membrane proteins, and carbohydrates. Therefore, we can say that the cell membrane is made of a phospholipid bilayer, but it is not only made of it.

DNA is responsible for transmitting genetic information by the sequencing of monomers known as_______

Answers

Answer:

nucleotides

Explanation:

a family goes on a vacation and returns home to find all their houseplants have wilted. at a cellular level, what is causing the plants to wilt?

Answers

When a family goes on vacation, they come home to find that all of their houseplants have wilted because the cells lack sufficient water pressure to support them. Because there is no water in the vacuole, the cell becomes weaker, which makes the plants wilt.

What of the following causes plants to wilt when watered with a salt solution?

Soil salts have the ability to hold water. Less water is thus available for plant uptake, exacerbating water stress and root dehydration.

which phrases give instances of aided diffusion?

phrases best sum up aided diffusion ,Through specific membrane proteins, solutes transverse the membrane along their gradient of concentration. Small, neutral molecules leave a cell along their gradient of concentration.

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8. which of the following cells are capable of forming a whole animal? a. a totipotent stem cell like a zygote b. embryonic stem cells c. enucleated eggs into which a somatic cell nucleus has been transplanted d. ipscs e. two of the above answers are correct

Answers

The Answer is e. Two of the above answers are correct

Totipotent stem cells are cells that have the capacity to self-renew by dividing and to develop into the three primary germ cell layers of the early embryo and into extra-embryonic tissues such as the placenta.

What is Placenta?

An organ that develops in the uterus during pregnancy. Placenta provides oxygen and nutrients to a growing baby. It also removes waste products from the baby's blood. It attaches to the wall of the uterus, and the baby's umbilical cord arises from it.

What is called Germ Cell?

A reproductive cell of the body is called a germ cell. These are egg cells in females and sperm cells in males.

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because the genetic code is redundant, meaning there are many codons that code for the same amino acid, which statement is most likely to occur?

Answers

Even though the genetic code was redundant (more than 1 codon may define the same amino acid), it is unambiguous; no codon provides and over one amino acid.

What is an example of genetic code?

genetic code, the arrangement of nucleotides in DNA and RNA that dictates the order of amino acids in proteins.Although DNA's linear nucleotide sequence provides the knowledge of protein sequences, protein are not synthesised directly from DNA.

What exactly is the genetic code, and why is it significant?

The genetic code aids in predicting the protein's amino acid sequence from of the genetic material.The amino acid sequence of a protein enables us to predict its shape and comprehend some of its characteristics and functions.

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describe a properly controlled experiment

Answers

Answer:

A controlled experiment is a scientific test done under controlled conditions, meaning that just one (or a few) factors are changed at a time, while all others are kept constant.

Explanation:

A good example would be an experiment to test drug effects. The sample receiving the drug would be the experimental group while the sample receiving a placebo would be the control group. While all variables are kept similar (e.g. age, sex, etc.) the only difference between the groups is the taking of medication.

PLEASE HELP ITS ABT A PUNNET SQUARE ILL MARK YOU BRAINLIST

Answers

Answer:C. Yy

Explanation:took it-

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He is happy that he learned a different education than his family. which of the following federal administrative agencies enforces disclosure provisions and regulations under the magnuson-moss warranty act? 2. What is an amendment?O When a law is declared to be unconstitutionalAn addition or change to the ConstitutionO a bill passed by the house The diagram shows a sector of a circle radius 10 cm.Find the perimeter of the sector, giving your answer correct to 1 decimal place. 24. The following fractions compare the number of free throws made to the number taken bybasketball players:Smith:1319Haller:12/20Dennis:14/17Ballard:17/22Rank the free throw accuracy of these players from lowest to highest. Justify. The cumberland gap is located on the border of the mississippi river. Was located in 1750 by daniel boone. Is another name for the wilderness road. Was a natural pass running through the appalachians. 66. 7 ml of ethanol was dissolved in 222. 2 ml of water. What is the volume % of the ethanol in the solution?. Use the graph of f(x) to find the following values.a)f(-4)b)f(-5)c)f(3)d)f(4) i need this asap pleaseee The FBI determined the true average time between felony acts in the US with a 95% confidence interval of (2.3, 5.7) seconds. Which of the following (if any) are correct? There is a 95% probability that the true average is between 2.3 and 5.7 seconds 95% of all felonies happen in 2.3 seconds to 5.7 seconds We are 95% confident the true average is between 2.3 and 5.7 seconds 95% of the time the true average will be between 2.3 and 5.7 seconds 95% of the time confidence intervals like this capture the true average time between a felony A new confidence interval has a 95% probability of capturing the sample average 100 Points + Brainliest if correct and well explained:A recent survey at a local recreation center reported that 79% of the participants played pickleball. Of those who play pickleball, 6% are female. Of those who do not play pickleball, 21% are male. Based on this information, construct a two-way relative frequency table. Round all values to the nearest whole percentage. Male Female TotalPlays pickleball 77% 2% 79%Does not play pickleball 6% 15% 21%Column Totals 83% 17% 100% Male Female TotalPlays pickleball 74% 5% 79%Does not play pickleball 4% 17% 21%Column Totals 78% 22% 100% Male Female TotalPlays pickleball 75% 4% 79%Does not play pickleball 4% 17% 21%Column Totals 79% 21% 100% Male Female TotalPlays pickleball 76% 3% 79%Does not play pickleball 4% 17% 21%Column Totals 80% 20% 100% the principal must assist the agent in the performance of his or her duties, and the principal can do nothing to interfere with the reasonable conduct of the agent. this is known as the duty of indemnification. How do online pharmacies challenge the traditional business model of pharmacies and drug firms