Which individuals help you determine if this trait is dominant or recessive?

Answer:

True

Explanation:

Abstract

The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of function mutations in the genes encoding dystrophin, or the associated proteins, triggers instability of the plasma membrane and myofiber loss. Mutations in dystrophin have been extensively cataloged providing remarkable structure-function correlation between predicted protein structure and clinical outcomes. These data have highlighted dystrophin regions necessary for in vivo function and fueled the design of viral vectors and now, exon skipping approaches for use in dystrophin restoration therapies. However, dystrophin restoration is likely more complex, owing to the role of the dystrophin complex as a broad cytoskeletal integrator. This review will focus on dystrophin restoration, with emphasis on the regions of dystrophin essential for interacting with its associated proteins and discuss the structural implications of these approaches.

Keywords: muscular dystrophy, dystrophin, spectrin repeat, exon skipping, sarcoglycan, sarcolemma

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INTRODUCTION

Muscular dystrophy is a collection of inherited diseases characterized by skeletal muscle weakness and degeneration. Muscular dystrophies are progressive disorders because over time healthy muscle fibers are lost and replaced by fibrosis and fat, making muscle tissues less able to generate force for everyday activity. As muscle wasting ensues, patients experience weakness, although muscle groups may be targeted differently in specific forms of muscular dystrophy. Respiratory failure, resulting from the weakening of breathing muscles, may limit lifespan in muscular dystrophy unless mechanical support is instituted. In some forms of muscular dystrophy, the heart is also affected resulting in cardiac complications including heart failure and irregular heart rhythms.

Duchenne muscular dystrophy (DMD) is one of the most common forms of muscular dystrophy. DMD is caused by recessive mutations in the dystrophin gene on X chromosome, affecting 1 in 3,500 to 5,000 newborn males worldwide (82). Boys with DMD show signs of muscle weakness early in childhood, typically between 2 and 7 years of age, and often lose ambulation around the time of puberty. DMD boys may have delayed development of motor skills such as sitting, walking and talking. Becker muscular dystrophy (BMD) is also caused by mutations in the DMD gene that encodes dystrophin. Individuals with BMD share similar signs and symptoms with DMD boys but with later onset and more varied time course. Like DMD, the heart can be affected in BMD.

The dystrophin gene is the largest known human gene, containing 79 exons and spanning > 2,200 kb, roughly 0.1% of the whole genome (96). The most common mutation responsible for DMD and BMD is a deletion spanning one or multiple exons. Such deletions account for 60–70% of all DMD cases and 80~85% BMD cases (58, 147). Point mutations are responsible for around 26% of DMD cases and 13% BMD cases. Exonic duplications account for 10 to 15% of all DMD cases and 5% to 10% BMD cases. Subexonic insertions, deletions, splice mutations and missense mutations account for the rest of the cases. DMD is associated with mutations that disrupt the protein’s reading frame causing premature stop codons. These mutated transcripts are susceptible to nonsense mediate decay, and the carboxy-terminal truncated protein products are also unstable and subject to degradation, leaving little or no protein produced in cells. In contrast, BMD patients usually have in-frame deletions that maintain the correct reading frame. Furthermore, nonsense mutations have been associated with both BMD and DMD. However, nonsense mutations associated with BMD are more prone to induce exon skipping than those found in DMD (59). The resulting protein products in BMD are internally truncated and expressed at lower levels than normal muscle. However, these internally truncated proteins are expressed at higher levels than in DMD and remain partially functional. Within one BMD affected family, three males carrying the same nonsense mutation in exon 29 displayed phenotypes from severe, mild to asymptomatic. This nonsense mutation is located in an exon recognition sequence in exon 29 and induces partial skipping of exon 29, producing an internally truncated dystrophin. A considerable amount s

Dystrophin is a complex structure that acts as an anchor, which connects the muscle cell cytoskeleton to the lattice of the protein and other extracellular matrix molecules.

It acts as a subsarcolemmal rod-shaped protein having a function to stabilize the sarcolemma, by connecting the extracellular matrix to the actin cytoskeleton through the dystrophin-associated glycoprotein complex.

This connection through the dystrophin-associated glycoprotein complex for sarcolemma maintains muscle cells from contraction-induced damage.

Dystrophin myofibril is a protein complex located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). This is located at the muscle sarcolemma.

Therefore, dystrophin is a complex structure that connects the muscle cell cytoskeleton to the extracellular matrix.

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Answer:

I would go for alveoli

Explanation:

Cus

Answer:

They help scientists observe things that are very small.

Explanation:

Geologists use a lot of tools to aid their studies. Some of the most common tools used are compasses, rock hammers, hand lenses, and field books.

Answer: it’s “They help Scientists observe thing that are very small”

Explanation: mostly the last one if I’m right! I hope this helps!!!

Answer:

This is beryllium

Explanation:

If you had a periodic table to work off of, it would be a bit easier, because normally the protons and atomic number are the same.

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Buy and use multipurpose cleaners.

Buy the least harmful product. Read labels.

Wipe up spills when they happen.

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A correct flow chart is DNA i.e., gene (transcription) >> mRNA + tRNAs (translation) >> amino acids or protein >> phenotype.  It is the flow of the genetic information.

The flow of genetic information refers to the molecular process from DNA to the final phenotype (i.e., protein product).

During gene transcription, a particular fragment of DNA called gene is used as a template to generate an mRNA.

Subsequently, the mRNA serves as a template to generate a linear chain of amino acids, i.e., a protein, by a process called translation.

The final protein can be considered as the phenotype (in this case, the albinism trait) because it is the observable feature.

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Answer:

39. Graph A because there would be a good habitat for Eagle populations to strive.

40. Graph A shows an idea of habitat quality because the Eagle population is living without ecological issues.

41.  Graph A will change over time due to the number of resources left to be consumed

Explanation:

Cause I said so (lol jk it kind of was in the answers)

Answer:

A bacteria culture starts with 500 bacteria and doubles in size every half hour. (a) How many bacteria are there after 3 hours? (b) How many bacteria are there after hours? (c) How many bacteria are there after 40 minutes? (d) Graph the population function and estimate the time for the population to reach 100,000.

Explanation:

it hope it helps

Primary consumers and secondary consumers are both heterotrophs. These organisms cannot produce their own food.

In a food web, consumers are heterotrophic organisms that need to eat other organisms to survive.

Primary consumers such as herbivores and secondary consumers such as carnivores are heterotrophic animals because they cannot produce their own food.

These animals are mutually related in a food web because the removal of primary consumers may lead to a decrease (even removal) in the population of the next trophic level.

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Yeah this is right answer

Answer:

i think its 5×5×5×5×5 According to the permutation formula in mathematics

Not sure what basic means in this context but it would be considered alkaline and definitely not acidic so I'd say basic.

Most ethical discussions about genome editing center on human germline editing because changes are passed down to future generations.

Answer:

Even if editing human genes is ethical, it would certainly cost money to edit your children. With that said, people with more money would be able to create stronger, faster, and smarter children. Anyone without enough disposable income would have normal babies. In essence, the physical capabilities of future people would be split by class. Thus, is it ethical to allow the divide by social class to be exacerbated by gene editing?

Answer: Biogeography is the study of the geographical distribution of plants, animals, and other forms of life. (Second part of question is in explanation)

Explanation: Biogeography gives information about how as well as when species might have matured. Fossils provide evidence of extended evolutionary  changes, noting the earlier actuality of species that are now extinct.

Answer:

A is the answer and the only one that makes sense...

Explanation:

we only make surfaces that the water can't get to the ground through, though we have combated this with drains it's still the only effect we have...

Answer:

B: it has a high specific heat

Occupational profile leads to more opportunities of employment on higher position in the coming future.

“The occupational profile is a summary of an individual about his/her occupation, experiences, living style, interests etc.

Participation of children or adults in the occupational profiles leads to more opportunities of employment on higher position in the future

These improvements are the reflection of experience and personality which needs a company and thus it can benefit the person so we can conclude that occupational profile make improvements n the life of child or adult.

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Answer:

False

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MRIs and fMRIs produce high-resolution, three-dimensional images. So, option D is correct.

MRI stands for Magnetic Resonance Imaging. It is a type of scanning that produces detailed images of the inside of the body by using a strong magnetic field and radio waves.

The spatial resolution of EEGs (electroencephalography) is comparatively low as compared to MRI and fMRI. While the temporal resolution of EEGs is as high as that of the others two. The spatial resolution of EEGs is low because it lacks the precision of scanning images.

Therefore, MRIs and fMRIs produce high-resolution, three-dimensional images.

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Answer:

D. MRIs and fMRIs

Explanation:

Answer:

3

Both DNA and RNA have four nitrogenous bases each—three of which they share (Cytosine, Adenine, and Guanine) and one that differs between the two (RNA has Uracil while DNA has Thymine). ... One of the most significant similarities between DNA and RNA is that they both have a phosphate backbone to which the bases attach.

Nerve cells transmit taste signals to the brain.