The anthropologist that conducted a now-classic study of cultural variation in the 1930s was a. Horace Miner. C. Margaret Mead. B. Napoleon Chagnon. D. George Murdock. Please select the best answer from the choices provided A B C D.

Yeah this is right answer

Abstract

The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of function mutations in the genes encoding dystrophin, or the associated proteins, triggers instability of the plasma membrane and myofiber loss. Mutations in dystrophin have been extensively cataloged providing remarkable structure-function correlation between predicted protein structure and clinical outcomes. These data have highlighted dystrophin regions necessary for in vivo function and fueled the design of viral vectors and now, exon skipping approaches for use in dystrophin restoration therapies. However, dystrophin restoration is likely more complex, owing to the role of the dystrophin complex as a broad cytoskeletal integrator. This review will focus on dystrophin restoration, with emphasis on the regions of dystrophin essential for interacting with its associated proteins and discuss the structural implications of these approaches.

Keywords: muscular dystrophy, dystrophin, spectrin repeat, exon skipping, sarcoglycan, sarcolemma

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INTRODUCTION

Muscular dystrophy is a collection of inherited diseases characterized by skeletal muscle weakness and degeneration. Muscular dystrophies are progressive disorders because over time healthy muscle fibers are lost and replaced by fibrosis and fat, making muscle tissues less able to generate force for everyday activity. As muscle wasting ensues, patients experience weakness, although muscle groups may be targeted differently in specific forms of muscular dystrophy. Respiratory failure, resulting from the weakening of breathing muscles, may limit lifespan in muscular dystrophy unless mechanical support is instituted. In some forms of muscular dystrophy, the heart is also affected resulting in cardiac complications including heart failure and irregular heart rhythms.

Duchenne muscular dystrophy (DMD) is one of the most common forms of muscular dystrophy. DMD is caused by recessive mutations in the dystrophin gene on X chromosome, affecting 1 in 3,500 to 5,000 newborn males worldwide (82). Boys with DMD show signs of muscle weakness early in childhood, typically between 2 and 7 years of age, and often lose ambulation around the time of puberty. DMD boys may have delayed development of motor skills such as sitting, walking and talking. Becker muscular dystrophy (BMD) is also caused by mutations in the DMD gene that encodes dystrophin. Individuals with BMD share similar signs and symptoms with DMD boys but with later onset and more varied time course. Like DMD, the heart can be affected in BMD.

The dystrophin gene is the largest known human gene, containing 79 exons and spanning > 2,200 kb, roughly 0.1% of the whole genome (96). The most common mutation responsible for DMD and BMD is a deletion spanning one or multiple exons. Such deletions account for 60–70% of all DMD cases and 80~85% BMD cases (58, 147). Point mutations are responsible for around 26% of DMD cases and 13% BMD cases. Exonic duplications account for 10 to 15% of all DMD cases and 5% to 10% BMD cases. Subexonic insertions, deletions, splice mutations and missense mutations account for the rest of the cases. DMD is associated with mutations that disrupt the protein’s reading frame causing premature stop codons. These mutated transcripts are susceptible to nonsense mediate decay, and the carboxy-terminal truncated protein products are also unstable and subject to degradation, leaving little or no protein produced in cells. In contrast, BMD patients usually have in-frame deletions that maintain the correct reading frame. Furthermore, nonsense mutations have been associated with both BMD and DMD. However, nonsense mutations associated with BMD are more prone to induce exon skipping than those found in DMD (59). The resulting protein products in BMD are internally truncated and expressed at lower levels than normal muscle. However, these internally truncated proteins are expressed at higher levels than in DMD and remain partially functional. Within one BMD affected family, three males carrying the same nonsense mutation in exon 29 displayed phenotypes from severe, mild to asymptomatic. This nonsense mutation is located in an exon recognition sequence in exon 29 and induces partial skipping of exon 29, producing an internally truncated dystrophin. A considerable amount s

Dystrophin is a complex structure that acts as an anchor, which connects the muscle cell cytoskeleton to the lattice of the protein and other extracellular matrix molecules.

It acts as a subsarcolemmal rod-shaped protein having a function to stabilize the sarcolemma, by connecting the extracellular matrix to the actin cytoskeleton through the dystrophin-associated glycoprotein complex.

This connection through the dystrophin-associated glycoprotein complex for sarcolemma maintains muscle cells from contraction-induced damage.

Dystrophin myofibril is a protein complex located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). This is located at the muscle sarcolemma.

Therefore, dystrophin is a complex structure that connects the muscle cell cytoskeleton to the extracellular matrix.

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Answer: Biogeography is the study of the geographical distribution of plants, animals, and other forms of life. (Second part of question is in explanation)

Explanation: Biogeography gives information about how as well as when species might have matured. Fossils provide evidence of extended evolutionary  changes, noting the earlier actuality of species that are now extinct.

Answer:

the Grand Canyon of Yellowstone and the Himalayas

Explanation:

i dont know why tbh but those are the answers :p

An example formed by Metamorphic rocks would be the Grand Canyon of Yellowstone, and the Himalayas. Thus, the correct options are A and F.

Metamorphic rocks is a type of rock which have been substantially changed from their original form such as igneous, sedimentary, or earlier metamorphic form into mature metamorphic rock. The metamorphic rocks are formed when rocks are subjected to high temperature, pressure, hot mineral-rich fluids and, more commonly combination of these factors.

Some common examples of Metamorphic rocks are the Grand Canyon of Yellowstone and the Himalayas. The most common forms of metamorphic rocks are slates, schists and gneisses.

Therefore, the correct options are A and F.

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Pangea began to split around 200 million years ago, and the first primates ensued around 85 million years ago.

When a three-pronged fracture developed between Africa, South America, and North America, Pangea first started to split apart. A volcanic rift zone was formed when magma welled up through the crustal weakness and rifting started.

As these split, continent-sized pieces of Pangea divided, volcanic explosions threw ash and volcanic debris throughout the terrain.

North America was being gradually pushed away from the rift zone and westward. A sequence of down-dropped fault blocks that closely parallel today's coastline were created as a result of the heavy continental crust that made up the new east coast collapsing.

Therefore, Pangea began to split around 200 million years ago, and the first primates ensued around 85 million years ago.

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Answer:

C

Explanation:

u pairs with a, a pairs with t, c pairs with g, and g pairs with c

Answer:

C

Explanation:

For mutation to occur

It must affect hereditary material

Answer:

1 . clay soil : contains finer particles

sandy soil : contains larger particles

2 . clay soil : it is fertile

sandy soil : it is not fertile

3 : clay soil : particles are tightly packed

sandy soil : Particles are loosely packed

4 : clay soil : High water retention capacity

sandy soil : Low water retention capacity

5 : clay soil : Good for growing various crops

sandy soil : Not suitable for growing crops

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Nerve cells transmit taste signals to the brain.

Answer:

Single-cell proteins develop when microbes ferment waste materials (including wood, straw, cannery, and food-processing wastes, residues from alcohol production, hydrocarbons, or human and animal excreta). They are found in very low concentrations, usually less than 5%. Engineers have developed ways to increase the concentrations including centrifugation, flotation, precipitation, coagulation, and filtration, or the use of semi-permeable membranes.

Explanation:

I believe this is right I'm sorry if it isn't

Answer: the height?

Explanation: not too sure on this one

Answer:

during meiosis, an event known as chromosomal crossing over sometimes occurs as a part of recombination. In this process, a region of one chromosome is exchanged for a region of another chromosome, thereby producing unique chromosomal combinations that further divide into haploid daughter cells.

Transcription is the process of making RNA from DNA molecules and it occurs in the nucleus.

Translation is process of making proteins from mRNA and tRNA molecules .

Transcription is the process where DNA molecules are used to synthesize RNA molecules.

Transcription occurs in the nucleus and the RNA produced is mRNA.

Translation is the process whereby mRNA is used to make proteins.

It is also known as protein synthesis.

Translation occurs at the ribosomes in the cytoplasm.

mRNA and tRNA molecules are used to synthesize proteins.

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if the Greeks had knowledge of modern biological practices the humors responsible for fluids. nowadays we know that fluids are those substances that are permanently in the body and whose production does not depend on external stimuli.

The Hippocratic theory of the four humors, present in the work On the Nature of Man, constitutes the human body from four fluids:

According to the treaty, health would be maintained by a balance between these four humors.

With this information, we know that fluids are those substances that are permanently in the body and whose production does not depend on external stimuli.

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Answer:

transporting anitbodies

Explanation:

Pashmina carpet from northern India uses repeated, stylized flowers as MOTIFS to create a unified design. The Huqqa base is a type of Indian metalwork.

The pashmina carpets are a specific type of carpet developed in northern India around the 17th century.

Pashmina carpets are very popular around the world due they are developed using soft materials.

Moreover, the Huqqa base is a class of Indian metalwork called bidri, which was developed in Bidar (north-eastern part of Karnataka state in India) in the 19th century.

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Answer:

This is beryllium

Explanation:

If you had a periodic table to work off of, it would be a bit easier, because normally the protons and atomic number are the same.

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Answer:

endoderm!

Explanation:

The tube-within-a-tube plan allows specialization of parts along the tube, such as a stomach, intestine, etc.

Hope this helps! :)

Answer:

The growth and aquatic plants and algae, but also the death of fish and other invertebrates.

Answer:

it helps break down food

Explanation:

:)

6 CO2 + 6 H20 -->  C6H12O6 + 6O2

6 Carbon dioxide + 6 Water -> Fructose + 6 Oxygen

Answer:

Aspirin, ibuprofen, or acetaminophen.

Explanation:

Answer:

I would go for alveoli

Explanation:

Cus