Three criteria can be used to rank candidate target sites for therapeutic use:
number of mismatches between the sgRNA and DNA sequence, proximity to genes,and presence of regulatory elements. Why is this so ?Target site 1 is the best option for therapeutic use because it has only one mismatch between the sgRNA and DNA sequence, is located near a regulatory element,and is likely to be effective in treating the disease.
Note that regulatory elements are sequences of DNA that control the expression of genes. They can be used to turn genes on or off, or to control the amount of protein that is produced from a gene.
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how do dominant autosomal genes affect a punnett square and the probability?
Dominant autosomal genes have a specific effect on Punnett squares and the probability of inheriting certain traits. When a dominant allele is present, it only requires one copy of the allele to be expressed in the phenotype. In Punnett squares, the dominant allele is represented by a capital letter, while the recessive allele is represented by a lowercase letter.
When a parent with a dominant allele mates with a parent with a recessive allele, the Punnett square shows the possible combinations of alleles that their offspring can inherit. In this case, if the dominant allele is present in one of the parents, it will always be expressed in the phenotype of the offspring. Therefore, the probability of inheriting the dominant trait is 100% for offspring that receive the dominant allele.
For example, if a parent with the dominant allele (AA) mates with a parent with the recessive allele (aa), all of their offspring in the Punnett square will have the genotype Aa, and they will express the dominant trait. The probability of inheriting the dominant trait is 100% for these offspring.
Dominant autosomal genes in Punnett squares ensure that the dominant trait is expressed in the phenotype of the offspring when at least one copy of the dominant allele is present.
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The drawing below was sketched by a student who was observing cells under a microscope.
In what kingdom does the above cell likely belong?
Answer:
protista
Explanation:
It just looks like a protista cell, I think
ASAP PLEASE HELP!!!!
When rock in the interior of the planet is heated to high enough temperatures, what occurs? Select the best answer from the choices below.
a it gets hotter and sinks into a trench
b the rock melts to create magma
c it forms new mountains underwater
d it causes glaciers to melt
Answer:
B !
Explanation:
I'm basing this off of a lesson I took two years ago, but the answer is B! The interior of Earth is rumored to be filled with magma as a way to have convection currents in itself, and to move the tectonic plates/ create the tectonic plates, if I remember correctly.
If i'm wrong I can still prove why it's not the other choices.
It's not A becuase when rock gets hotter, it rises, and when it cools, it sinks.
it's not C becuase it said "interior of the planet", which it may be referencing somewhere having to do to below the crust. as well, you need to cool rocks as to make it solid, not heated up rocks. but even then, mountains are made by the plates.
it's not D becuase glaciers are affected by climate change and occurrences the biosphere, not the interior of the planet.
Which of the following steps stops the feedback
mechanism that begins when a person's body
temperature falls below 37.C?
O A. The blood vessels slow blood flow to the
skin.
B. The brain senses that the body temperature
has reached 37°C.
C. The muscles begin to contract rapidly.
O D. The person begins to sweat.
Answer:
dont know sry
Explanation:
??????????????
Answer: B
Explanation: The brain senses that the body temperature has reached 37°C
5. Predict long-term changes to the surface landscape of the area if too much water is drawn from the ground and the water table drops further.
Spong father is a heterozygous squarepants and her mother is a roundpants, what are
her parents' possible genotypes?
Answer:
(a) If SpongeGerdy's father is a heterozygous squarepants and her mother is a ... possible genotypes that would result to help you determine Gerdy's genotype. ... sponge. She knows that they have a 50% chance of having a little roundpants, ... be blue (a recessive trait) like SpongeSusie and many members of her family.
Explanation:
You list three places/examples of how ATP is used
Answer: places- ATP hydrolysis provides the energy needed for many essential processes in organisms and cells. These include intracellular signaling, DNA and RNA synthesis, Purinergic signaling, synaptic signaling, active transport, and muscle contraction. examples- ATP is used to build large molecules such as proteins, to temporarily store energy in the form of fat, and to allow for all types of cellular transport. brainliest
Explanation:
Ki,ss me if I'm wrong. But dinosaurs still exist right?
Answer:
No, dinosaurs have died out a long time ago!
But did you know that dragonflies used to exsist back then? They were way bigger than they are now. Alot of animals are evolutionalized versions of their prehistoric forms!
Explanation:
Is it possible for directional selection to create a new species? How?
Answer:
Directional selection occurs when individuals with traits on one side of the mean in their population survive better or reproduce more than those on the other. ... However, directional selection does not always result in evolution, because it can be constrained in many ways.
Explanation:
Which cellular process is most related to the function of the mitochondria?
A
diffusion
B
mitosis
С C
osmosis
D
respiration
Compare the concentration of connective tissue cells found in bone with the concentration of those found in blood.
Answer: CONNECTIVE TISSUE is the most abundant tissue in the body which are widely separated from each other and intercellular substance (matrix) is present in considerably larger amounts. The principal cell of connective tissue are fibroblasts which makes fibres found in almost all connectiv tissues. Some are solid and strong (bone), while others are fluid and flexible( blood).
Explanation:
Connective tissues usually contain fibres present in the matrix which may be of semisolid jelly-like consistency or dense and rigid, depending upon the position and function of the tissue. There are three main types of connective tissue which include:
--> Loose connective tissue
--> Dense connective tissue and
--> specialised connective tissue.
The bone and the blood are considered to be an example of specialised connective tissue. This is so because they both contain a number of different tissues with specialized cells and unique ground substances.
The BONE consists of osteoblasts, osteocytes, and osteoclasts. It is considered to be a specialised connective tissue because the bone cells are surrounded by a matrix of collagen fibres strengthened by inorganic salts, especially calcium and phosphate.
The BLOOD consists of red blood cells, white blood cells, platelets. It is considered to be a specialised connective tissue because the blood cells are surrounded by fluid matrix known as plasma and connecta with other cells through its transport functions.
In COMPARING the concentration of connective tissue cells or bone and blood, the connective tissue cells of bone comsist of fibre and collagen which makes it dense and rigid while the connective tissue cells of blood does not contain any fibre, therefore it's flexible.
Ground shaking can transform wet sediments into liquid-like slurries in a process known as O a liquefaction O b. sloping O c slumping O d undercutting
Liquefaction occurs when the ground shaking transforms wet sediments into liquid-like slurries in a process known as liquefaction. The correct option is A) Liquefaction.
Liquefaction is a process where loose, unconsolidated soil loses its strength due to an increase in pore water pressure that reduces the effective stress between soil particles. Liquefaction is the tendency of soil to lose strength in response to earthquake shaking or other rapid loading. The ground behaves as a liquid because of the increase in pore water pressure that occurs as the soil particles are pressed against each other.
Liquefaction is a type of ground failure that occurs in saturated, loose, sandy soils due to seismic loading, and it has caused a lot of damage in past earthquakes. During an earthquake, the pore water pressure in the soil rises and reduces the soil's strength. The water-filled voids in the soil compress under increased stress, causing the soil to behave like a liquid and lose its ability to support the weight of buildings and other structures. This results in the collapse of buildings, bridges, and other infrastructure. Therefore, ground shaking can transform wet sediments into liquid-like slurries in a process known as liquefaction.
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What is the chirality in a polysaccharide chain
Answer:
the first answer is a virus
Explanation:
Which of the following scenarios would cause high compliance? A. High compliance would result in the lung collapsing on itself B. Increased production of elastic fibers in the alveolar walls C. Increased destruction of elastic fibers in the alveolar walls D. Decreased production of surfactant
High compliance would result from increased production of elastic fibers in the alveolar walls. This would enhance lung tissue elasticity, allowing for easier expansion during breathing, option B is correct.
Increased production of elastic fibers in the alveolar walls would lead to high compliance. Compliance refers to the lung's ability to expand and stretch in response to changes in pressure during breathing. Elastic fibers provide the lungs with their elastic properties, allowing them to easily stretch and recoil. When there is an increased production of elastic fibers, it enhances the overall elasticity of the lung tissue.
This increased elasticity means that the lungs can readily expand and accommodate a larger volume of air during inhalation. As a result, high compliance is achieved, enabling efficient and effective breathing, option B is correct.
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The complete question is:
Which of the following scenarios would cause high compliance?
A. High compliance would result in the lung collapsing on itself
B. Increased production of elastic fibers in the alveolar walls
C. Increased destruction of elastic fibers in the alveolar walls
D. Decreased production of surfactant
what do animals in the eukarya domain have in common?
Help me!!
Answer:
The domain Eukarya keep the genetic material
inside of the nucleus.
Explanation:
Which of the following amino acids have R groups that are hydrophilic? Glutamine, Glutamic Acid, Cysteine A) Glutamine, Glutamic Acid, and Cysteine are all hydrophilic B) Only Glutamine and Glutamic Acid are hydrophilic C) Only Glutamine and Cysteine are hydrophilic D) Only Glutamic Acid is hydrophilic
C) Only Glutamine and Cysteine amino acids have R groups that are hydrophilic.
Amino acids are the basic structural units of proteins. They are organic molecules that contain both an amino group (-NH₂) and a carboxyl group (-COOH), as well as a side chain (R group) that varies in structure from one amino acid to the next.
The side chain of an amino acid is often referred to as the R group. Depending on the type of R group, amino acids can be classified as hydrophobic or hydrophilic. The R groups of some amino acids are hydrophobic, while the R groups of others are hydrophilic.
Hydrophilic amino acids are polar and can form hydrogen bonds with water molecules. Hydrophobic amino acids, on the other hand, are nonpolar and do not form hydrogen bonds with water molecules. The R groups of glutamine and cysteine are hydrophilic. The answer is option C) Only Glutamine and Cysteine are hydrophilic.
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Why might some siblings in a family show the trait of albinism while others don't?
Answer:
Even if both parents carry the gene, the chance of each of their children being born with albinism is one in four. If just one parent has the gene and the other parent has a normal pigment gene, their children won't have oculocutaneous albinism.
Explanation:
An organism is multicellular and lacks a cell wall. Use this table to determine the kingdom in which it belongs. justify your answer.
What is the condition of outside air a certain time and place
O Climate zone
O Weather
O Climate
O Element
categorize each carbohydrate listed as either a monosaccharide, disaccharide, or polysaccharide.glucosecellulosesucrosefructosestarch
A brief explanation of each category:
Monosaccharide: Monosaccharides are the simplest form of carbohydrates and cannot be further hydrolyzed into smaller units. They consist of a single sugar molecule. Glucose and fructose are examples of monosaccharides.
Disaccharide: Disaccharides are formed by the combination of two monosaccharide units through a glycosidic bond. Sucrose is an example of a disaccharide, composed of glucose and fructose.
Polysaccharide: Polysaccharides are complex carbohydrates composed of many monosaccharide units linked together. They can be hydrolyzed into smaller sugar units. Cellulose and starch are examples of polysaccharides. Cellulose is a structural polysaccharide found in the cell walls of plants, while starch is a storage polysaccharide in plants.
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True or False?
The convection currents in the mantle
are mainly caused by heat coming
from the core.
Answer:
true
Explanation:
convection currents occur when a heated fluid expands, becoming less dense, and rises. The fluid then cools and contracts, becoming more dense, and sinks
heat go up, cold go down. they cycle.
Answer:
False
Explanation:
Could someone PLEASE HELP ME !
Answer:
c
Explanation:
Can i get brainlists
Water goes in the direction of the solute (salt). What happens to the cell in the first picture?
a. The cell shrinks due to water loss.
b. The cell expands due to water absorption.
c. The cell remains unchanged.
d. The cell undergoes division.
The correct option is (a). When water goes in the direction of the solute (salt), the cell in the first picture shrinks due to water loss.
When water goes in the direction of the solute (salt), the cell in the first picture shrinks due to water loss.What is absorption? Absorption is the process by which materials pass through the lining of the digestive system into the bloodstream. Absorption is a chemical reaction in which one substance permeates another. Substances that have dissolved in a solvent, such as water, are called solutes. Water is the solvent, and the solute in this scenario is salt. Water moves from a region of higher concentration to a region of lower concentration to equalize concentrations on both sides of the cell membrane. Because salt has a lower concentration, water travels towards it, causing the cell to shrink due to the loss of water. What is a solute?
A solute is a substance that dissolves in a solvent to form a solution. A solute is dissolved in a solvent to create a homogeneous mixture known as a solution. A solute can be a solid, liquid, or gas, and it can be a single substance or a mixture. The substance that dissolves the solute is known as the solvent. The concentration of a solution is determined by the quantity of solute dissolved in a solvent. Water is the most frequent solvent in biological processes due to its capability to dissolve a wide range of substances.
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Which of the following regarding most developing countries is true?
a. They have just completed the demographic transition.
b. They have experienced or are in various phases of the ec. idemiologic transition but have not completed the fertility transition.
d. They have not yet begun to enter the initial phase of the demographic transition.
e. They have experienced the fertility transition but not the epidemiologic transition.
Regarding the majority of emerging countries, it is true that the demographic shift has just been accomplished. However, the change in developing nations didn't begin until the second half of the 20th century. Hence (a) is the correct option.
Although the population grew by up to three to four percent annually, the change took place more quickly. In many developing nations, the transformation process is still ongoing. A phenomenon and theory in demography known as demographic transition describes the historical change from high birth and death rates in societies with little technology, education (especially for women), and economic development to low birth and death rates in societies with advanced technology.
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Based on the characteristics of fruiting plants shown in the table, which statement accurately reflects the placement of the cucumber into a taxonomic group? Cucumbers are fruits that grow on plants with long, trailing vines and fuzzy leaves. Select ALL options that apply. A) Cucumbers likely share a genus with pumpkins but not a class. B) Cucumbers likely share a class with pumpkins but not a genus. C) Cucumbers share more taxonomic groups with eggplants that with pumpkins. D) Cucumbers and pumpkins would likely share more taxonomic groups than cucumbers and okra share. E) Cucumbers share more taxonomic groups with peppers than with any other plant listed in the table.
Answer: B and D
Explanation: I just got it wrong
Answer:
the answer is B & D
I got the test wrong and here is the answers
Following fertilization and two rounds of cell cleavage, each of the four cells of a frog embryo has a centriole that is preparing for the next cleavage. The centriole in each of these cells can trace its origins back to the original centriole provided by the _______ prior to the first cleavage. Please choose the correct answer from the following choices, and then select the submit answer button. Answer choices secondary oocyte sperm ootid oogonium primary oocyte
Answer:
sperm
Explanation:
Centrioles are cylindrical organelles that play a major role during cell division, where they work to form the centrosome which duplicates and moves to opposite ends of the cell. The proximal centriole provided by the sperm cell mediates the separation of chromatids during the first cleavage of the fertilized egg. Upon fertilization, the proximal centriole forms the aster rays where microtubules act as a guide for the migration of the female pronucleus.
Explain the concept of 'natural selection' and what it really means. Specify what
mechanism actually causes the natural selection and why it occurs.
Answer:
Natural selection is a proccess that occurs when an oganism is to weak to survive against other predators in that environementIt has failed to find a suitable nihe and evolution will cause it to become extinct from that geographic area.
Natural selection is the theory behind evolution put forth by Charles Darwin. Given the scarcity of resources in nature, animals with heritable features that promote survival and reproduction will typically produce more offspring than their contemporaries, leading to an increase in the frequency of such traits across successive generations.
Why is natural selection important?Charles Darwin's theory of evolution is known as natural selection. Animals with heritable qualities that aid in survival and reproduction will often generate more offspring than their contemporaries due to the limited resources in nature, increasing the frequency of such traits through subsequent generations.
Favorable features are passed down across generations as a result of natural selection. Natural selection may result in speciation, the process by which one species gives rise to another that is utterly separate.
It is one of the mechanisms that propels evolution and contributes to the understanding of the variety of life on Earth.
Thus, this is the main concept of natural selection.
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Solar system included all of the following except what?
Answer: Stars?
Explanation: I think it is stars because there is only one star in our solar system. I don't know for sure if it is, but I think it is. Don't be too sure of my answer.
What are the different features of the Moon’s surface?
Answer:
Craters, hills, and various spots.
Explanation:
Explain why some of your arterioles dilate while others construct during exercise.
Answer:
It looks at the role of adenosine triphosphate, or ATP, a chemical that can be released by red blood cells and is believed to cause blood vessels to dilate during exercise, when muscles demand more oxygen.
Explanation:
Hope this helped Mark BRAINLIEST!!!